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Methylprednisolone-drug interactions When combined with other drugs that are known to have similar side effects, Methylprednisolones most serious drug-drug interactions may occur when: Taken in combination with other medications known to cause similar adverse effects If the other medication impacts the blood levels of methylprednisolone Methylprednisolone impacts the circulating concentrations of the other medication These interactions include both prescription drugs and over-the-counter medications